Acne is that the nemesis of the many teens, and even some adults. Now, researchers say they may have hit on a brand new approach to easing the condition.
The key lies in a very naturally made skin oil known as secretion, explained a hunt team light-emitting diode by William Esler, a scientist with drug big Pfizer in Cambridge, Massachusetts.
Sebum is very important to the skin's health as a result of it helps regulate temperature and repel microbes, the team aforementioned. however associate degree more than secretion production has conjointly long been thought to be a contributor to disease of the skin.
"Too a lot of secretion will get treed in glands, that cause it to swell and cause a bump below the skin," explained Dr Raman Madan, a skin doctor with Northwell Health's Huntington Hospital in Huntington, New York.
So, it stands to reason that characteristic "a target to decrease secretion production would be a unique approach to treating disease of the skin," aforementioned Madan, World Health Organization wasn't concerned within the new study.
The analysis concerned a microscopic examination of the skin of twenty-two healthy volunteers. Esler's team discovered that skin secretion production depends on a particular molecular mechanism called the Diamond State novo lipogenesis (DNL) pathway.
Most secretion was found to be made by cells known as sebocytes, that secreted the oil supported the ebb and flow of the DNL pathway, the researchers explained.
But 9 folks with disease of the skin showed one major difference: Compared to folks with traditional skin, they'd a two hundredth higher rate of secretion production and a connected rise in fluctuations of the DNL pathway, the findings showed.
Going a step any, Esler's cluster designed a compound that targeted associate degree protein concerned within the pathway. In healthy volunteers, application of the treatment cut secretion production by nearly 0.5, consistent with the report printed in Science translational drugs.
Of course, these experiments ar early and it remains to be seen if such a compound may curb secretion – and disease of the skin – in a very larger, a lot of rigorous trial.
In the meanwhile, Madan aforementioned that the approach "has potential". however he cautioned that "this is also a treatment for disease of the skin, however not a cure, as a result of the reason behind disease of the skin is quite simply secretion production. it's potential to be associate degree addition to current treatments."
Dr Michele inexperienced could be a skin doctor at Lenox Hill Hospital in the big apple town. She united that the findings "may supply promise to patients suffering with disease of the skin vulgaris".
Image credit: iStock
The key lies in a very naturally made skin oil known as secretion, explained a hunt team light-emitting diode by William Esler, a scientist with drug big Pfizer in Cambridge, Massachusetts.
A bump below the skin
Sebum is very important to the skin's health as a result of it helps regulate temperature and repel microbes, the team aforementioned. however associate degree more than secretion production has conjointly long been thought to be a contributor to disease of the skin.
"Too a lot of secretion will get treed in glands, that cause it to swell and cause a bump below the skin," explained Dr Raman Madan, a skin doctor with Northwell Health's Huntington Hospital in Huntington, New York.
So, it stands to reason that characteristic "a target to decrease secretion production would be a unique approach to treating disease of the skin," aforementioned Madan, World Health Organization wasn't concerned within the new study.
The analysis concerned a microscopic examination of the skin of twenty-two healthy volunteers. Esler's team discovered that skin secretion production depends on a particular molecular mechanism called the Diamond State novo lipogenesis (DNL) pathway.
Most secretion was found to be made by cells known as sebocytes, that secreted the oil supported the ebb and flow of the DNL pathway, the researchers explained.
Sebum production cut in 0.5
But 9 folks with disease of the skin showed one major difference: Compared to folks with traditional skin, they'd a two hundredth higher rate of secretion production and a connected rise in fluctuations of the DNL pathway, the findings showed.
Going a step any, Esler's cluster designed a compound that targeted associate degree protein concerned within the pathway. In healthy volunteers, application of the treatment cut secretion production by nearly 0.5, consistent with the report printed in Science translational drugs.
Of course, these experiments ar early and it remains to be seen if such a compound may curb secretion – and disease of the skin – in a very larger, a lot of rigorous trial.
In the meanwhile, Madan aforementioned that the approach "has potential". however he cautioned that "this is also a treatment for disease of the skin, however not a cure, as a result of the reason behind disease of the skin is quite simply secretion production. it's potential to be associate degree addition to current treatments."
Dr Michele inexperienced could be a skin doctor at Lenox Hill Hospital in the big apple town. She united that the findings "may supply promise to patients suffering with disease of the skin vulgaris".
Image credit: iStock